Study on the diagnostic value of VEGF, CA19-9 and CEA in pancreatic cancer and the risk factors of vascular invasion

Background: Pancreatic cancer is a malignant tumor of the gastrointestinal tract. Due to its insidious onset, most patients with newly diagnosed pancreatic have missed opportunity for radical surgery, which offers best chance survival. The 5-year survival rate can be improved early diagnosis, and serum makers are an inexpensive convenient diagnostic tool that widely used in diagnosis malignancies. Objective: To determine value vascular endothelial growth factor (VEGF), carbohydrate antigen 19-9 (CA 19-9), carcinoembryonic (CEA) risk factors invasion. Methods: An experimental group comprising 52 admitted our department from July 2021 2022 control 21 benign diseases during same period were included study. Their VEGF, CA 19-9, CEA levels detected compared between two groups, correlation three markers invaded vessel non-invaded groups was investigated. single marker combination analyzed, different pathological characteristics compared. Results: had higher than (P < 0.05). Through receiver operating characteristic (ROC) curve analysis, combined detection highest cancer, area under (AUC) 0.9158 (95% CI: 0.8415–0.9900), while sensitivity specificity 76.19% 98.08%, respectively. Serum VEGF stage III–IV those metastasis I–II without 0.05), Binary logistic regression analysis performed invasion results showed only OR CI): 1.001–1.006. Conclusion: Patients significantly levels, high clinical diagnosis. In addition, independent predict certain extent.